CBDS is cell-based drug screening system. It is a biological exploration system using a special cell strain manufacturing technology for controlling gene .

CHEBIGEN is to secure newly functional candidate substances by using the CBDS system, which has better functionality than the existing screening system, and establish the function of a new substance and a target gene in cooperation with related organizations.By establishing the derivatives technology, CHEBIGEN is building a Chemical Library and promoting the development ofanin vivo(cell-based drug) exploration system.

	Existing System (In Vitro)th>	Our System (In Vivo)
AP-1 repressor	Biochemical method that measures the activation of MEK, p38, MAPK, or JNK, a phosphorylation enzyme, which is important to the AP-1 activation - HTS, typical method	Directly measures the tranional activation of AP-1 in a specially manufactured animal cell - ExploresHTS under physiological conditions
Estrogen substitute	A substance combined with ER receptor protein is explored through a filter assay. - Competition assay that uses radiolabeled estrogen	A substance combined with ER receptor protein is explored through a filter assay. - Competition assay that uses radiolabeled estrogen
Fat bolism regulator	A substance combined with PPAR receptor protein is explored through filter assay. - Competition assay that uses radiolabeled Wy-14643	Directly measures the tranional activation of PPAR in a specially manufactured animal cell - ExploresHTS under physiological conditions